Rodríguez-Muela Lab
Selective Neuronal Vulnerability in Neurodegenerative Diseases

Most recent Publications of the Rodriguez-Muela Lab

 

  1. Ines Rosignol, Zeynep Dokuzluoglu, Antonio Caldarelli, Ana-Maria Oprişoreanu, Sofiia Ushakova, Tohid Siddiqui, Rahul Grover, Hannes Guerlich, Björn Falkenburger, Stefan Diez, Tobias Grass, Catherina  G. Becker, Natalia Rodriguez-Muela Altered lysosomal biology impairs motor neuron survival via TFEB dysregulation in spinal muscular atrophy bioRxiv 2025.07.07.663525; doi: https://doi.org/10.1101/2025.07.07.663525

  2. Felix Buchner, Zeynep Dokuzluoglu, Joshua Thomas, Antonio Caldarelli, Shrutika Kavali, Fabian Rost, Tobias Grass, Natalia Rodríguez-Muela Synchronous 3D patterning of diverse CNS progenitors generates motor neurons of broad axial identity bioRxiv 2024.12.13.628384; doi: https://doi.org/10.1101/2024.12.13.628384

  3. Grass, T.; Dokuzluoglu, Z. ; Rodríguez-Muela, N.
    Neuromuscular Organoids to Study Spinal Cord Development and Disease.
    Organoids / Turksen, Kursad (Editor) ; New York, NY : Springer US, 2025, Chapter 574 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-0716-4681-6=978-1-0716-4682-3 ; doi:10.1007/978-1-0716-4682-3 New York, NY : Springer US, Methods in Molecular Biology 2951, 197 – 219 (2025) [10.1007/7651_2024_574]

  4. Grass T., Dokuzluoglu Z., Buchner F., Rosignol I., Thomas J., Buchner F., Calderelli A., Dalinskaya A., Becker J., Wirth B., Rodriguez-Muela N. An isogenic human iPSC model unravels unnoticed neurodevelopmental abnormalities in spinal muscular atrophy (2024). Cell Reports Medicine. doi: 10.1016/j.xcrm.2024.101659  
  5. Felix Buchner, Zeynep Dokuzluoglu, Tobias Grass, Natalia Rodríguez-Muela. Spinal Cord Organoids to Study Motor Neuron Development and Disease (2023). Life , 13(6), 1254; doi: 10.3390/life13061254.
  6. Siddiqui, T.; Cosacak, MI  ; Popova, S.  ; Bhattarai, P.  ; Yilmaz, E.  ; Lee, AJ  ; Min, Y.  ; Wang, X.  ; Allen, M.  ; İş, Ö.  ; Atasavum, ZT  ; Rodriguez-Muela, N.  ; Vardarajan, BN  ; Flaherty, D.  ; Teich, AF  ; Santa-Maria, I.  ; Freudenberg, U.  ; Werner, C.  ; Tosto, G.  ; Mayeux, R.  ; Ertekin-Taner, N.  ; Kizil, C. Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer’s disease.npj regenerative medicine8(1),33(2023)[10.1038/s41536-023-00311-5]
  7. Felix Lansing, Liliya Mukhametzyanova, Teresa Rojo-Romanos, Kentaro Iwasawa, Masaki Kimura, Maciej Paszkowski-Rogacz, Janet Karpinski, Tobias Grass, Jan Sonntag, Paul Martin Schneider, Ceren Günes, Jenna Hoersten, Lukas Theo Schmitt, Natalia Rodriguez-Muela , Ralf Knöfler, Takanori Takebe, Frank Buchholz. Correction of a Factor VIII genomic inversion with designer-recombinases . Nat Commun. 2022 Jan 20;13(1):422. doi: 10.1038/s41467-022-28080-7.
  8. Natalia Rodríguez-Muela. Autophagy in motor neuron diseases. Book chapter. Advances in Molecular Biology and Translational Science . Volume 172 , 2020, Pages 157-202. doi: 10.1016/bs.pmbts.2020.03.009.
  9. Rodriguez-Muela N # (leading corresponding author), Parkhitko A, Grass T, Gibbs R, Norabuena E, Perrimon N, Singh R, Rubin LL # . Blocking p62/SQSTM1- dependent SMN degradation ameliorates the Spinal Muscular Atrophy disease phenotype . J Clin Invest. 2018 Jul 2;128(7):3008-3023 . doi: 10.1172/JCI95231.
  10. Patricia Boya, Patrice Codogno and Natalia Rodriguez-Muela. Autophagy in stem cells: repair, remodeling, and metabolic reprogramming. Development. 2018 Feb 26;145(4). doi: 10.1242/dev.146506.
  11. Rodriguez-Muela N # (leading corresponding author), Litterman NK, Norabuena EM, Mull JL, Galazo MJ, Sun C, Ng SY, Makhortova NR, White A, Lynes MM, Chung WK, Davidow LS, Macklis JD, Rubin LL # . Single-Cell Analysis of SMN Reveals Its Broader Role in Neuromuscular Disease. Cell Reports. 2017 Feb 7;18(6):1484-1498. doi: 10.1016/j.celrep.2017.01.035.
  12. Tripathi P, Rodriguez-Muela N , Klim JR, de Boer AS, Agrawal S, Sandoe J, Lopes CS, Ogliari KS, Williams LA, Shear M, Rubin LL, Eggan K, Zhou Q. Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β Stem Cell Reports. 2017 Aug 8;9(2):667-680. doi: 10.1016/j.stemcr.2017.06.008.
  13. Ng SY*, Soh BS*, Rodriguez-Muela N , Hendrickson DG, Price F, Rinn JL, Rubin LL. Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy Cell Stem Cell. 2015 Nov 5;17(5):569-84. doi: 10.1016/j.stem.2015.08.003.
  14. Rodríguez-Muela N , Koga H, García-Ledo L, de la Villa P, de la Rosa EJ, Cuervo AM, Boya, P. Balance between autophagic pathways preserves retinal homeostasis. Aging Cell. 2013 Jun;12(3):478-88. doi: 10.1111/acel.12072.